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Description:Potent20Sproteasomeinhibitor
ChemicalName:N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Potent20Sproteasomeinhibitor(IC50=0.22nM).Exhibitscytostaticandcytotoxiceffectsintumorcellsinvitro.
TechnicalData
| M.Wt | 475.63 |
| Formula | C26H41N3O5 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1211877-36-9 |
| PubChemID | 45103781 |
| InChIKey | TZYWCYJVHRLUCT-ZRBLBEILSA-N |
| Smiles | CC(C[C@@H](C=O)NC([C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)CC(C)C)=O)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.56 | 100 | |
| ethanol | 9.51 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight475.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.1mL | 10.51mL | 21.02mL |
| 5mM | 0.42mL | 2.1mL | 4.2mL |
| 10mM | 0.21mL | 1.05mL | 2.1mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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