BiologicalActivity
γ-secretaseinhibitor;inhibitsproteolyticcleavageofamyloidprecursorprotein(APP)overtheNotchpathway.ReduceslevelsofAβinthebrain(inhibitsAβ40andAβ42inSH-SY5YneuroblastomacellswithanIC50of0.65nM);attenuatesplaquedeposition.Orallybioavailable.
LicensingInformation
ManufacturedandsoldunderlicensefromMerck&Co.,Inc.forusesolelyforpreclinicalresearchpurposes(ie:notforadmiNISTrationtoorotheruseinhumans).
CompoundLibraries
MRK560isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 517.92 |
| Formula | C19H17ClF5NO4S2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 677772-84-8 |
| PubChemID | 11577204 |
| InChIKey | WDZVWDXOIGQJIO-UHFFFAOYSA-N |
| Smiles | ClC(C=C3)=CC=C3[S@]([C@@]1([C@]2=C(F)C=CC(F)=C2)CC[C@@H](NS(=O)(C(F)(F)F)=O)CC1)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.79 | 100 | |
| ethanol | 25.9 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight517.92.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.93mL | 9.65mL | 19.31mL |
| 5mM | 0.39mL | 1.93mL | 3.86mL |
| 10mM | 0.19mL | 0.97mL | 1.93mL |
| 50mM | 0.04mL | 0.19mL | 0.39mL |
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