BiologicalActivity
SelectiveCD45inhibitor(IC50=200nM).Exhibits>200-foldselectivityforCD45oversixrelatedproteintyrosinephosphatases.IncreasesphosphorylationofLckinJurkatcellsandreducesTcellreceptorsignalinginacitvatedsplenocytesinvitro.Blocksinflammationinadelayed-typehypersensitivitymodelinvivo.
TechnicalData
| M.Wt | 325.75 |
| Formula | C18H12ClNO3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 130089-98-4 |
| PubChemID | 781109 |
| InChIKey | LSQZKIQSQHZVQS-UHFFFAOYSA-N |
| Smiles | O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.58 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight325.75.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.07mL | 15.35mL | 30.7mL |
| 5mM | 0.61mL | 3.07mL | 6.14mL |
| 10mM | 0.31mL | 1.53mL | 3.07mL |
| 50mM | 0.06mL | 0.31mL | 0.61mL |
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