BiologicalActivity
Membranetype-1matrixmetalloproteinase(MT1-MMP)inhibitor(IC50>100μmol/L).Directlyinteractswiththehemopexindomain(PEX)ofMT1-MMP,affectinghomodimerizationandrepressingitspro-tumOrigenicactivityinvivo.DisplaysnoeffectonthecatalyticactivityofMT1-MMPorMMP-2.
CompoundLibraries
NSC405020isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 260.16 |
| Formula | C12H15Cl2NO |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 7497-07-6 |
| PubChemID | 346721 |
| InChIKey | ARDYECYBETXQFD-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C(NC(C)CCC)=O)C=C1Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.02 | 100 | |
| ethanol | 26.02 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight260.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.84mL | 19.22mL | 38.44mL |
| 5mM | 0.77mL | 3.84mL | 7.69mL |
| 10mM | 0.38mL | 1.92mL | 3.84mL |
| 50mM | 0.08mL | 0.38mL | 0.77mL |
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