品牌试剂实验Tocris代理 Tocris抗体,Tocris/NSC 87877/2613/50/50 mg,蛋白酶类,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/NSC 87877/2613/50/50 mg

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Tocris

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2613/50

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4000-520-616

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Description:Potentinhibitorofshp2andshp1PTP

ChemicalName:8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonicacid

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentinhibitorofshp2andshp1proteintyrosinephosphatases(PTP)(IC₅₀valuesare0.318,0.355,1.691,7.745,65.617,84.473and150.930μMforshp2,shp1,PTP1B,HePTP,DEP1,CD45andLARrespectively).InhibitsEGF-inducedErk1/2activationinHEK293cellsandsignificantlyreducesMDA-MB-468cellviABIlity/proliferation.

TechnicalData

M.Wt	459.45
Formula	C₁₉H₁₃N₃O₇S₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	56990-57-9
PubChemID	5459322
InChIKey	BIQBDHSYQMHHPU-CJLVFECKSA-N
Smiles	OC2=C(/N=N/C3=CC=C(C=C(S(=O)(O)=O)C=C4)C4=C3)C=C(S(=O)(O)=O)C1=CC=CN=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	9.19	20
	water	22.97	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight459.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.18mL	10.88mL	21.77mL
5mM	0.44mL	2.18mL	4.35mL
10mM	0.22mL	1.09mL	2.18mL
50mM	0.04mL	0.22mL	0.44mL

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BiologicalActivity

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