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Tocris/NSC 95397/1547/50/50 mg
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Tocris/NSC 95397/1547/50/50 mg
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Tocris
货号 / 
1547/50
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4000-520-616
Description:SelectiveCdc25dualspecificityphosphataseinhibitor
ChemicalName:2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveirreversIBLeinhibitorofCdc25dualspecificityphosphatases(Kivaluesare32,96and40nMforinhibitionofCdc25A,-Band-Crespectively).Displays125-180-foldselectivityoverVH1-relateddual-specificityphosphataseandproteintyrosinephosphatase1b.InhibitscarcinomacellgrowthandblocksG2/Mphasetransitioninvitro.

TechnicalData

M.Wt310.38
FormulaC14H14O4S2
StorageDesiccateat-20°C
Purity≥97%(HPLC)
CASNumber93718-83-3
PubChemID262093
InChIKeyMAASHDQFQDDECQ-UHFFFAOYSA-N
SmilesOCCSC1=C(SCCO)C(=O)C2=CC=CC=C2C1=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO15.5250
ethanol1.555

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight310.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.22mL16.11mL32.22mL
5mM0.64mL3.22mL6.44mL
10mM0.32mL1.61mL3.22mL
50mM0.06mL0.32mL0.64mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet