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Description:SelectiveCdc25dualspecificityphosphataseinhibitor
ChemicalName:2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentandselectiveirreversIBLeinhibitorofCdc25dualspecificityphosphatases(Kivaluesare32,96and40nMforinhibitionofCdc25A,-Band-Crespectively).Displays125-180-foldselectivityoverVH1-relateddual-specificityphosphataseandproteintyrosinephosphatase1b.InhibitscarcinomacellgrowthandblocksG2/Mphasetransitioninvitro.
TechnicalData
M.Wt | 310.38 |
Formula | C14H14O4S2 |
Storage | Desiccateat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 93718-83-3 |
PubChemID | 262093 |
InChIKey | MAASHDQFQDDECQ-UHFFFAOYSA-N |
Smiles | OCCSC1=C(SCCO)C(=O)C2=CC=CC=C2C1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 15.52 | 50 | |
ethanol | 1.55 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight310.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.22mL | 16.11mL | 32.22mL |
5mM | 0.64mL | 3.22mL | 6.44mL |
10mM | 0.32mL | 1.61mL | 3.22mL |
50mM | 0.06mL | 0.32mL | 0.64mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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