BiologicalActivity
Potent,orallyactivedipeptidylpeptidase(DPP)-IVinhibitor(Ki=11nM,IC50=14nM)thatdisplays>15000-foldselectivityoverDPP-IIandarangeofproline-cleavingproteases.Exhibitsantidiabeticactivityinvivo;improvesglucosetolerance,increasesglucagon-likepeptide1(GLP-1)andinsulinlevels,augmentsinsulinsecretionandGLUT2levels,andreduces(preserves)isletsize.
CompoundLibraries
NVPDPP728dihydrochlorideisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 371.27 |
| Formula | C15H18N6O.2HCl |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 207556-62-5 |
| PubChemID | 9799555 |
| InChIKey | VNACOBVZDCLAEV-GXKRWWSZSA-N |
| Smiles | O=C(N2CCC[C@H]2C#N)CNCCNC1=NC=C(C#N)C=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.13 | 100 | |
| water | 37.13 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight371.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.69mL | 13.47mL | 26.93mL |
| 5mM | 0.54mL | 2.69mL | 5.39mL |
| 10mM | 0.27mL | 1.35mL | 2.69mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
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