BiologicalActivity
Broadspectrumserineproteaseinhibitor.Displaysselectivityforhumantryptasewhenusedatrelativelylowconcentrations.Reduceseosinophilinfiltration,mastcellactivationandairwayresponsivenessinamurinemodelofasthma.
CompoundLibraries
NafamostatmesylateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 539.59 |
| Formula | C19H17N5O2.2CH4O3S |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 82956-11-4 |
| PubChemID | 54953 |
| InChIKey | SRXKIZXIRHMPFW-UHFFFAOYSA-N |
| Smiles | CS(=O)(O)=O.NC(C1=CC=C2C(C=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=C2)=C1)=N.CS(=O)(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.96 | 100 | |
| water | 53.96 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight539.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.85mL | 9.27mL | 18.53mL |
| 5mM | 0.37mL | 1.85mL | 3.71mL |
| 10mM | 0.19mL | 0.93mL | 1.85mL |
| 50mM | 0.04mL | 0.19mL | 0.37mL |
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