BiologicalActivity
Inhibitorofubiquitin-specificprotease(USP)7(EC50=8.6μM);alsoinhibitsthecloselyrelateddeubiquitinase(DUB)USP47.DemonstratesdownstreaminhibitionofHDM2andclaspininvitro.InhibitsUSP7-mediatedp53deubiquitination.BlocksdeubiquitinationofTip60(KAT5)histonelysineacetyltransferase.
CompoundLibraries
P22077isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 315.32 |
| Formula | C12H7F2NO3S2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1247819-59-5 |
| PubChemID | 46931953 |
| InChIKey | RMAMGGNACJHXHO-UHFFFAOYSA-N |
| Smiles | CC(C1=CC([N+]([O-])=O)=C(SC2=CC=C(F)C=C2F)S1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.53 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight315.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.17mL | 15.86mL | 31.71mL |
| 5mM | 0.63mL | 3.17mL | 6.34mL |
| 10mM | 0.32mL | 1.59mL | 3.17mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |
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