BiologicalActivity
Selectiveinhibitorofubiquitin-specificprotease(USP)7(IC50=4.2μM).Displayslittle-to-noinhibitionofotherUSPvariantsorproteasessuchascaspase,cathepsinsandserineproteases;exhibitssomeactivityatUSP47.Induceselevatedp53andapoptosisincancercelllines;displaysantiangiogenicactivityinvivo.
TechnicalData
| M.Wt | 348.22 |
| Formula | C12H7Cl2NO3S2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 882257-11-6 |
| PubChemID | 2819993 |
| InChIKey | LKZLGMAAKNEGCH-UHFFFAOYSA-N |
| Smiles | CC(=O)C1=CC(=C(SC2=CC=CC(Cl)=C2Cl)S1)[N+]([O-])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.48 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight348.22.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.87mL | 14.36mL | 28.72mL |
| 5mM | 0.57mL | 2.87mL | 5.74mL |
| 10mM | 0.29mL | 1.44mL | 2.87mL |
| 50mM | 0.06mL | 0.29mL | 0.57mL |
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