BiologicalActivity
Procaspase-activatingcompound;activatesprocaspase-3toproducecaspase-3(EC50=0.22μM).Alsoactivatesprocaspase-7inalessefficientmanner(EC50=4.5μM).Pro-apoptotic;inducesapoptosisinbothcancerousandnon-cancerouscellsdependentonprocaspase-3concentration(IC50valuesare0.003-1.41and5.02-9.98μMrespectively).
CompoundLibraries
PAC1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 392.5 |
| Formula | C23H28N4O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 315183-21-2 |
| PubChemID | 9675990 |
| InChIKey | YQNRVGJCPCNMKT-LFVJCYFKSA-N |
| Smiles | O=C(N/N=C/C3=CC=CC(CC=C)=C3O)CN(CC2)CCN2CC1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 29.44 | 75 | |
| DMSO | 39.25 | 100 | |
| ethanol | 19.63 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight392.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.55mL | 12.74mL | 25.48mL |
| 5mM | 0.51mL | 2.55mL | 5.1mL |
| 10mM | 0.25mL | 1.27mL | 2.55mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |
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