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Tocris/PK 44 phosphate/4145/10/10 mg

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Tocris

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4145/10

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4000-520-616

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Description:PotentandselectivedipeptidylpeptidaseIV(DPP-IV)inhibitor

ChemicalName:(3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanonephosphate

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentinhibitorofdipeptidylpeptidaseIV(DPP-IV)(IC₅₀=15.8nM).Displays>1000-foldselectivityforDPP-IVoverDPP-8andDPP-9.Improvesglucosetoleranceinamouseoralglucosetoleranceassay.

CompoundLibraries

PK44phosphateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	527.34
Formula	C₁₇H₁₆F₅N₇O.H₃PO₄
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1017682-66-4
PubChemID	90488917
InChIKey	IRIGBESJZBGJOS-DDWIOCJRSA-N
Smiles	N[C@@H](CC(N4CC3=NN=C(C(F)(F)F)N3CC4)=O)CC2=NNC1=C(F)C(F)=CC=C12.OP(O)(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	52.73	100
	water	52.73	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight527.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.9mL	9.48mL	18.96mL
5mM	0.38mL	1.9mL	3.79mL
10mM	0.19mL	0.95mL	1.9mL
50mM	0.04mL	0.19mL	0.38mL

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BiologicalActivity

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