BiologicalActivity
Highlypotentandselectiveinhibitorof glutamatecarboxypeptidase2(GCPII/N-acetylatedα-linkeddipeptidase/NAALADase)withaKivalueof275pM.Neuroprotective;protectsagainstglutamate-mediatedmotorneurondegenerationandreducesvolumeofinjuryfollowingmiddlecerebralarteryocclusion(MCAO).
LicensingInformation
SoldwiththepermissionofAstraZenecaLtd.
TechnicalData
| M.Wt | 226.12 |
| Formula | C6H11O7P |
| Storage | DesiccateatRT |
| CASNumber | 173039-10-6 |
| PubChemID | 10130754 |
| InChIKey | ISEYJGQFXSTPMQ-UHFFFAOYSA-N |
| Smiles | OC(=O)CCC(CP(=O)(O)O)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.61 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight226.12.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.42mL | 22.11mL | 44.22mL |
| 5mM | 0.88mL | 4.42mL | 8.84mL |
| 10mM | 0.44mL | 2.21mL | 4.42mL |
| 50mM | 0.09mL | 0.44mL | 0.88mL |
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