BiologicalActivity
Broadspectrum,reversIBLeDUBinhibitor.Exhibitslimitedactivityagainstotherproteases.Inducesaccumulationofpolyubiquitinatedproteins,buthasnodirectinhibitoryeffectontheproteasome.CytotoxicinHEK293Tandcolorectalcancercells.StABIlizesmicrotubulenetworkinoligodendroglialcells.
TechnicalData
| M.Wt | 223.28 |
| Formula | C7H5N5S2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 2645-32-1 |
| PubChemID | 2817763 |
| InChIKey | ZXOBLNBVNROVLC-UHFFFAOYSA-N |
| Smiles | NC1=C(SC#N)C=C(SC#N)C(N)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.23 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight223.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.48mL | 22.39mL | 44.79mL |
| 5mM | 0.9mL | 4.48mL | 8.96mL |
| 10mM | 0.45mL | 2.24mL | 4.48mL |
| 50mM | 0.09mL | 0.45mL | 0.9mL |
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