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Description:Neutralendopeptidaseandendothelinconvertingenzymeinhibitor
ChemicalName:N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophandisodiumsalt
Purity:≥95%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Neutralendopeptidase(neprilysin)inhibitor.BlocksdegradationofamyloidβpeptidesandincreasesAβlevelsinrodents.Alsoblocksendothelinconvertingenzyme(ECE).
TechnicalData
M.Wt | 587.47 |
Formula | C23H32N3Na2O10P |
Storage | Storeat-20°C |
Purity | ≥95%(HPLC) |
CASNumber | 164204-38-0 |
PubChemID | 16219931 |
InChIKey | OQKHVXFOYFBMDJ-ODIUWQMJSA-L |
Smiles | CC(C[C@@H](C(N[C@H](C(O[Na])=O)CC1=CNC2=CC=CC=C12)=O)NP(O[C@@H]3O[C@H]([C@@H]([C@H]([C@H]3O)O)O)C)(O[Na])=O)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
water | 58.75 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight587.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.7mL | 8.51mL | 17.02mL |
5mM | 0.34mL | 1.7mL | 3.4mL |
10mM | 0.17mL | 0.85mL | 1.7mL |
50mM | 0.03mL | 0.17mL | 0.34mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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