Tocris批发，产品货源 Tocris小分子,Tocris/Rupintrivir/6414/5/5 mg,蛋白酶类,Tocris,Bio-Techne,,5 mg蚂蚁淘商城

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Tocris/Rupintrivir/6414/5/5 mg

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Tocris

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6414/5

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4000-520-616

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Description:PotentandselectiveirreversIBLehumanrhinovirus3Cproteaseinhibitor

ChemicalName:Ethyl(2E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoate

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectiveirreversiblehumanrhinovirus(HRV)3Cproteaseinhibitor(EC₅₀=5nM).Exhibitsnosignificantinhibitionagainstavarietyofserineandcysteineproteases.Inhibitsreplicationofapanelof48differentHRVSEROtypesinH1-HeLAandMRC-5cellprotectionassays.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt	598.66
Formula	C₃₁H₃₉FN₄O₇
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	223537-30-2
PubChemID	6440352CAY
InChIKey	CAYJBRBGZBCZKO-BHGBQCOSSA-N
Smiles	O=C(C1=NOC(C)=C1)N[C@@H](C(C)C)C(C[C@@H](CC2=CC=C(F)C=C2)C(N[C@H](/C=C/C(OCC)=O)C[C@@H]3CCNC3=O)=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	59.87	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight598.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.67mL	8.35mL	16.7mL
5mM	0.33mL	1.67mL	3.34mL
10mM	0.17mL	0.84mL	1.67mL
50mM	0.03mL	0.17mL	0.33mL

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BiologicalActivity

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