BiologicalActivity
PTPN2andPTENinhibitor(IC50valuesare0.95and1.78μM,respectively).IncreasesfMLP-elicitedPIP3signaling,Akt-phosphorylationandproductionofreactiveoxygenspeciesinneutrophilsinvitro.Pretreatmentoftransfusedneutrophilsenhanceschemotaxistositesofbacterialinfectionandincreasessurvivalinneutropenicmice.AlsoinhibitsCD45.
TechnicalData
| M.Wt | 307.34 |
| Formula | C19H17NO3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 345630-40-2 |
| PubChemID | 9926586 |
| InChIKey | VZQDDSYKVYARDW-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC=C1C3=C(C=C(NC(C(C)(C)C)=O)C=C3)C2=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.73 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight307.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.25mL | 16.27mL | 32.54mL |
| 5mM | 0.65mL | 3.25mL | 6.51mL |
| 10mM | 0.33mL | 1.63mL | 3.25mL |
| 50mM | 0.07mL | 0.33mL | 0.65mL |
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