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Description:CathepsinLinhibitor
ChemicalName:N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentandreversIBLehumancathepsinLinhibitor(IC50=56nM).DisplaysnoinhibitoryactivityatcathepsinG.Antimalarial;inhibitsleishmaniasis.
TechnicalData
| M.Wt | 539.65 |
| Formula | C27H33N5O5S |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 958772-66-2 |
| PubChemID | 16725315 |
| InChIKey | OTIWAYTTYNFEKL-QFIPXVFZSA-N |
| Smiles | O=C(NNC(SCC(NC1=C(CC)C=CC=C1)=O)=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(OC(C)(C)C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.98 | 50 | |
| ethanol | 5.4 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight539.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.85mL | 9.27mL | 18.53mL |
| 5mM | 0.37mL | 1.85mL | 3.71mL |
| 10mM | 0.19mL | 0.93mL | 1.85mL |
| 50mM | 0.04mL | 0.19mL | 0.37mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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