BiologicalActivity
Cell-permeableinhibitorofcellularphosphatasecomplexesthatdephosphorylateeukaryotictranslationinitiationfactor2subunitα(eIF2α).Analogofsalubrinal(Cat.No.2347)withimprovedaqueoussolubility.Showntopreventtheinductionofhippocampallong-termpotentiation(LTP)andmemoryformation(LTM)inmice.
CompoundLibraries
Sal003isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 463.21 |
| Formula | C18H15Cl4N3OS |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1164470-53-4 |
| PubChemID | 5717737 |
| InChIKey | TVNBASWNLOIQML-IZZDOVSWSA-N |
| Smiles | S=C(NC(NC(/C=C/C2=CC=CC=C2)=O)C(Cl)(Cl)Cl)NC1=CC=C(Cl)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.32 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight463.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.16mL | 10.79mL | 21.59mL |
| 5mM | 0.43mL | 2.16mL | 4.32mL |
| 10mM | 0.22mL | 1.08mL | 2.16mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |
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