BiologicalActivity
InhibitoroftheregulatorysubunitPPP1R15Aofproteinphosphatase1.DoesnotbindPPP1R15Borhaveα2adrenergicagoNISTactivity.Cytoprotectiveinendoplasmicreticulumstressedcellsinvitro.PreventsdefectsassociatedwithproteinmisfoldinginamouseCharcot-MarieTooth-1Bmodel.Orallyavailable.
TechnicalData
| M.Wt | 258.66 |
| Formula | C8H9ClN4.CH2O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 121513868 |
| InChIKey | LCQVFBONUDQAEH-NKPNRJPBSA-N |
| Smiles | ClC1=C(/C=N/NC(N)=N)C=CC=C1.OC(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.87 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight258.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.87mL | 19.33mL | 38.66mL |
| 5mM | 0.77mL | 3.87mL | 7.73mL |
| 10mM | 0.39mL | 1.93mL | 3.87mL |
| 50mM | 0.08mL | 0.39mL | 0.77mL |
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