BiologicalActivity
Selectiveleukocyteelastaseinhibitor(IC50=44nM)thatdisplaysnoactivityatarangeofotherproteases.InhibitsNF-κBactivationandLTB4-inducedneutrophiltransmigrationinvitro.Significantlyattenuatesischemia-inducedspinalcordinjury,decreasesserumcytokinelevelsandreducesacuteinflammatorylunginjuryinvivo.
CompoundLibraries
SivelestatsodiumsaltisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 456.44 |
| Formula | C20H21N2NaO7S |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 150374-95-1 |
| PubChemID | 23664980 |
| InChIKey | ZAIFANJZUGNYCK-UHFFFAOYSA-M |
| Smiles | [Na+].CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=C1C(=O)NCC([O-])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.82 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight456.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.19mL | 10.95mL | 21.91mL |
| 5mM | 0.44mL | 2.19mL | 4.38mL |
| 10mM | 0.22mL | 1.1mL | 2.19mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
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