BiologicalActivity
HighlypotentandselectiveMMP13inhibitor(IC50=6.9pM).Exhibits>2600-foldselectivityforMMP13overrelatedMMPs.Inhibitsdegradationofbovinenasalseptumcartilageexplantsinvitro.Orallybioavailable.
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheT-26cprobesummaryontheSGCwebsite.
TechnicalData
| M.Wt | 523.47 |
| Formula | C24H19N3Na2O6S |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 869298-22-6 |
| InChIKey | MJSVEIMIMXVRNJ-UHFFFAOYSA-L |
| Smiles | COC1=CC=CC(CNC(C2=NC(C3=C(SC=C3COCC4=CC=C(C(O[Na])=O)C=C4)N2[Na])=O)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 0.52 | 1 | |
| DMSO | 5.23 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight523.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.91mL | 9.55mL | 19.1mL |
| 5mM | 0.38mL | 1.91mL | 3.82mL |
| 10mM | 0.19mL | 0.96mL | 1.91mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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