生命科学Tocris价格优惠 Tocris多肽,Tocris/UK 370106/2900/10/10 mg,蛋白酶类,Tocris,Bio-Techne,,10 mg蚂蚁淘商城

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Tocris/UK 370106/2900/10/10 mg

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Tocris

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2900/10

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Description:HighlyselectiveMMP-3andMMP-12inhibitor

ChemicalName:(βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoicacid

Purity:≥95%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighlyselectiveMMP-3andMMP-12inhibitor(IC₅₀valuesare0.023,0.042,1.75,2.3,5.8,30.4,34.2and66.9μMatMMP3,12,8,13,7,9,2and14respectively.)Inhibitsfibronectincleavage(IC₅₀=320nM)andhaslittleeffectonkeratinocytemigrationinvitro.SubstantiallyinhibitsMMP-3inanexvivomodelofchronicdermalulcers.

TechnicalData

M.Wt	572.73
Formula	C₃₅H₄₄N₂O₅
Storage	Storeat-20°C
Purity	≥95%(HPLC)
CASNumber	230961-21-4
PubChemID	9808181
InChIKey	NSMABJUGSNPHMN-BHYWQNONSA-N
Smiles	CC(C=C(CCC[C@@H](C(N[C@@H]([C@@](C)(C)C)C(N[C@H](COC)C3=CC=CC=C3)=O)=O)CC(O)=O)C=C2)=C2C1=CC=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	57.27	100
	ethanol	14.32	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight572.73.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.75mL	8.73mL	17.46mL
5mM	0.35mL	1.75mL	3.49mL
10mM	0.17mL	0.87mL	1.75mL
50mM	0.03mL	0.17mL	0.35mL

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