BiologicalActivity
PotentandselectiveinhibitorofBMP-1(procollagenC-proteinase;PCP)(IC50=44nM).SelectiveforBMP-1overMMPs1,2,3,9and14(IC50valuesare>10,000nMforlistedMMPs).
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
UK383367isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 324.38 |
| Formula | C15H24N4O4 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 348622-88-8 |
| PubChemID | 9818682 |
| InChIKey | ARJCBSRIPGJMAD-LLVKDONJSA-N |
| Smiles | ONC(C[C@H](C2=NC(C(N)=O)=NO2)CCCC1CCCCC1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.44 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight324.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.08mL | 15.41mL | 30.83mL |
| 5mM | 0.62mL | 3.08mL | 6.17mL |
| 10mM | 0.31mL | 1.54mL | 3.08mL |
| 50mM | 0.06mL | 0.31mL | 0.62mL |
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ProductDatasheets
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