BiologicalActivity
Inhibitorofubiquitin-specificpeptidase4(USP4),USP5/isopeptidaseT(IsoT)andUCH-L1deubiquitinatingenzyme(DUB)activity(IC50valuesare1.5,5.9and22.3μM,respectively).ShowsnosignificantinhibitionofUCH-L3,USP2,andUSP8activities.DecreasesreleaseofTNF-α(IC50=0.09nM)fromRBL-2H3mastcells.Displaysanti-canceractivitydecreasingviABIlityinhumancoloniccarcinomacells.
TechnicalData
| M.Wt | 562.57 |
| Formula | C34H26O8 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 858134-23-3 |
| PubChemID | 11563133 |
| InChIKey | NOJUKCRPSUMHQQ-UHFFFAOYSA-N |
| Smiles | OC(C(O)=C(C3=CC=C(O)C=C3)C(OC(CC4=CC=CC=C4)=O)=C2OC(CC5=CC=CC=C5)=O)=C2C1=CC=C(O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.25 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight562.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.78mL | 8.89mL | 17.78mL |
| 5mM | 0.36mL | 1.78mL | 3.56mL |
| 10mM | 0.18mL | 0.89mL | 1.78mL |
| 50mM | 0.04mL | 0.18mL | 0.36mL |
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