BiologicalActivity
IrreversibleMALT1inhibitor.SuppressesTcellactivation-inducedcleavageofBcl-10inadose-dependentmanor.ReducesJurkatcelladhesiontofibronectin.Cellpermeable.
LicensingInformation
SoldunderlicencefromUNILunderthelicencedpatents
TechnicalData
| M.Wt | 790.81 |
| Formula | C31H49FN10O6.CF3CO2H |
| Sequence | VRPR (Modifications:Val-1=Z-Val,Arg-4=DL-Arg-fluoromethylketone) |
| Storage | Storeat-20°C |
| PubChemID | 121513848 |
| InChIKey | WIPHXOQUHDJLCU-WTJMUODPSA-N |
| Smiles | OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)CF |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwaterwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight790.81.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.26mL | 6.32mL | 12.65mL |
| 5mM | 0.25mL | 1.26mL | 2.53mL |
| 10mM | 0.13mL | 0.63mL | 1.26mL |
| 50mM | 0.03mL | 0.13mL | 0.25mL |
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