BiologicalActivity
PotentinhibitorofglutamatecarboxypeptidaseIIandIII(GCPIIandIII/NAAGpeptidase/NAALADase)(Kivaluesare0.8and23nMrespectively)thatinhibitsthehydrolysisofNAAG(IC50=2.4nM).DoesnotdirectlyinteractwithNMDAormetabotropicglutamatereceptors.Reducesneuronaldegenerationinaratmodelof traumaticbraininjury(TBI)andreduceslocomotoractivityinthePCP-modelofschizophrenia.
LicensingInformation
SoldwiththepermissionofAcentaDiscovery,Inc.
TechnicalData
| M.Wt | 304.3 |
| Formula | C12H20N2O7 |
| Storage | Storeat-20°C |
| CASNumber | 723331-20-2 |
| PubChemID | 11722553 |
| InChIKey | BSGWCSGMXAVYRT-YUMQZZPRSA-N |
| Smiles | CC(C[C@@]([H])(C(O)=O)NC(N[C@@]([H])(CCC(O)=O)C(O)=O)=O)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.43 | 100 | |
| water | 30.43 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight304.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.29mL | 16.43mL | 32.86mL |
| 5mM | 0.66mL | 3.29mL | 6.57mL |
| 10mM | 0.33mL | 1.64mL | 3.29mL |
| 50mM | 0.07mL | 0.33mL | 0.66mL |
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