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Description:InhibitorofMMP-2
ChemicalName:(R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
SelectiveinhibitorofMMP-2thatdisplays~600-foldselectivityoverMMP-1(IC50valuesare0.81and486nMrespectively).
TechnicalData
| M.Wt | 406.5 |
| Formula | C20H26N2O5S |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 849773-63-3 |
| PubChemID | 11292680 |
| InChIKey | DGZZVIWCMGVHGV-LJQANCHMSA-N |
| Smiles | O=S(C1=CC=C(C2=CC=CC=C2)C=C1)(N(OC(C)C)[C@H]([C@@H](C)C)C(NO)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.65 | 100 | |
| ethanol | 10.16 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight406.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.46mL | 12.3mL | 24.6mL |
| 5mM | 0.49mL | 2.46mL | 4.92mL |
| 10mM | 0.25mL | 1.23mL | 2.46mL |
| 50mM | 0.05mL | 0.25mL | 0.49mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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