
Overview:
IKKbetaisaserine/threonineproteinkinasethatphosphorylatestheI-kappa-BproteinwhichisaninhibitorofthetranscriptionfactorNF-kappa-Bcomplex.PhosphorylationofI-kappa-Bproteintriggersthedegradationoftheinhibitorviatheubiquitinationpathway,therebyactivatingNF-kappa-Bcomplex.TheactivityofIKKIKKbetaisstimulatedbyTNFandIL1andIKKbetaformsaheterodimerthatinteractswithNIK(1).OverexpressionofcatalyticallyinactiveIKKbetablockscytokine-inducedNF-kappa-Bactivation.AspirinandsodiumsalicylatecanspecificallyinhibitIKKbetaactivityinvitroandinvivobybindingtoIKKbetatoreduceATPbinding(2).
GeneAliases:
IKK2,IKBKB,IKKB,NFKBIKB,FLJ40509,IKK-beta,MGC131801
GenbankNumber:
NM_001556
References:
1.Woronicz,JD.etal:IkappaBkinase-beta:NF-kappa-BactivationandcomplexformationwithIkappaBkinase-alphaandNIK.Science278:866-869,1997.2.Yin,M.-J.etal:Theanti-inflammatoryagentsaspirinandsalicylateinhibittheactivityofI-kappa-Bkinase-beta.Nature396:77-80,1998.
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提RNA一般注意:提取前材料的保存(新鲜材料,过夜处理的样品),提取中对外源性的RNA酶的清除控制(离心管,PCR管,电泳槽,台面等的无RNA酶化处理),提取后需要-80度保存.其次跑电泳时,注意电泳液最好用新鲜的,核酸染料等诸多因素.
细菌总RNA提取试剂盒( germs islation kit).
对于外源性RNA酶的控制外源RNA酶清除剂,避免使用致癌物DEPC的危险方法就可简单操作清除耗材,台面,仪器等的外源RNA酶的降解作用.
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