
Overview:
TRKC is a member of the TRK family of tyrosine kinase receptors and is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). TRKC mediates the multiple cellular effects of the NT-3 neurotrophic factor, which includes neuronal differentiation and survival (1). TRKC has been implicated in insulin signaling pathway through interactions with the MUSK protein receptor and the VEGF receptor. Mutations in the TRKC gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers (2).
Gene Aliases:
NTRK3, gp145(trkC)
Genbank Number:
NM_001012338
References:
1. Lamballe, F. et al: trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3". Cell, 1991; 66 (5): 967-79. 2. Marchetti, A. et al: Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. Hum Mutat. 2008 May;29(5):609-16
ebiomall.com






>
>
>
>
>
>
>
>
>
>
>
>
提RNA一般注意:提取前材料的保存(新鲜材料,过夜处理的样品),提取中对外源性的RNA酶的清除控制(离心管,PCR管,电泳槽,台面等的无RNA酶化处理),提取后需要-80度保存.其次跑电泳时,注意电泳液最好用新鲜的,核酸染料等诸多因素.
细菌总RNA提取试剂盒( germs islation kit).
对于外源性RNA酶的控制外源RNA酶清除剂,避免使用致癌物DEPC的危险方法就可简单操作清除耗材,台面,仪器等的外源RNA酶的降解作用.
向左转|向右转

