| HNMPAcell impermeable tyrosine kinase inhibitor |
Sample solution is provided at 25 µL, 10mM.
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| Cas No. | 132541-52-7 | SDF | Download SDF |
| Synonyms | Hydroxy-2-naphthalenylmethyl Phosphonic Acid | ||
| Chemical Name | P-(hydroxy-2-naphthalenylmethyl)-phosphonic acid | ||
| Canonical SMILES | OC(P(O)(O)=O)C1=CC2=CC=CC=C2C=C1 | ||
| Formula | C11H11O4P | M.Wt | 238.2 |
| Solubility | ≤20mg/ml in ethanol;1mg/ml in DMSO;15mg/ml in dimethyl formamide | Storage | Store at -20°C |
| Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
HNMPA is a tyrosine kinase inhibitor that inhibited both the receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity [1].
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for growth factors, cytokines, and hormones. The insulin receptor is one of a number of growth factor receptors with intrinsic tyrosine kinase activity that can be activated upon ligands binding [1].
HNMPA (Hydroxy-2-naphthalenylmethyl Phosphonic Acid) is a tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation. HNMPA does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibited tyrosine kinase activity of autophosphorylated insulin receptor towards poly (Glu4, Tyr) or insulin receptor-(1155-1165) peptide by 82% and 81%, respectively. HNMPA also inhibited autophosphorylation of insulin receptors by 13% + 4.6% in the presence of insulin. HNMPA not only inhibited insulin receptor tyrosine phosphorylation but also effectively decreased insulin receptor serine phosphorylation [1]. In β-cells exposed to high glucose, HNMPA was able to further increase the exe-4-induced insulin secretion [2].
References:[1]. Baltensperger K, Lewis RE, Woon CW, et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7885-9.[2]. Moon MJ, Kim HY, Park S, et al. Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. Mol Cells. 2011 Oct;32(4):389-95.
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我做实验的药物很难买到标准品，但现在有粗品，自己在提纯，想问下各位大牛，在没有标准品的情况下，怎么测提纯后该物质的纯度。谢谢
我们维克奇专门做标准品/对照品的,产品纯度要大于等于百分之九十八,可以看看我们的网站信息
例用微物测定孢克罗效价用孢克罗标准品用HPLC或UV测定则用照品；非西丁用作熔点校准物质用熔点标准品测定含量用照品即使同种物质标准品照品规格、标定及用途都能同（北京标准物质网）
