BiologicalActivity
Potentandselectivefattyacidbindingprotein4,ADIpocyte(FABP4)inhibitor(Kivaluesare<2,250and350nMforFABP4,FABP3andFABP5respectively).Decreasesfattyaciduptakeinadipocytesinvitroandreducesatheroscleroticlesionareainamousemodelofatherosclerosis.Reducesbloodglucoselevelsandincreasesinsulinsensitivityinamousemodelofobesity.Orallyactive.
CompoundLibraries
BMS309403isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 474.55 |
| Formula | C31H26N2O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 300657-03-8 |
| PubChemID | 16122583 |
| InChIKey | SJRVJRYZAQYCEE-UHFFFAOYSA-N |
| Smiles | CCC1=C(C4=CC=CC=C4)C(C5=CC=CC=C5)=NN1C2=CC=CC=C2C3=CC=CC(OCC(O)=O)=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.45 | 100 | |
| ethanol | 9.49 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight474.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.11mL | 10.54mL | 21.07mL |
| 5mM | 0.42mL | 2.11mL | 4.21mL |
| 10mM | 0.21mL | 1.05mL | 2.11mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
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