BiologicalActivity
Acetyl-CoAcarboxylase(ACC)2and1inhibitor(IC50valuesare45and98nM,respectively).Reduceshepaticandskeletalmusclemalonyl-CoAlevelsinrats.Alsoinhibitshepaticdenovolipogenesisandreduceswholebodyrespiratoryexchangeratioinrats.Orallybioavailable.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 405.49 |
| Formula | C23H27N5O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1301214-47-0 |
| PubChemID | 52934180 |
| InChIKey | BDXXSFOJPYSYOC-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=C(N=C(C)N5)C5=C4)N1CCC(CC(C=NN3C(C)C)=C3C(C2)=O)2CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.27 | 50 | |
| ethanol | 8.11 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight405.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.47mL | 12.33mL | 24.66mL |
| 5mM | 0.49mL | 2.47mL | 4.93mL |
| 10mM | 0.25mL | 1.23mL | 2.47mL |
| 50mM | 0.05mL | 0.25mL | 0.49mL |
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