BiologicalActivity
Inhibitorofdiacylglycerollipase(IC50valuesare1.1and4μMinratcardiacmyocytesandcanineplateletsrespectively).WeaklyinhibitsphospholipasesCandA2.Potentiatesacetylcholineevokedrelaxationinmesentericarteriesbytheinhibitionofcholinesteraseactivity(IC50=4μM).
CompoundLibraries
RHC80267isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 394.51 |
| Formula | C20H34N4O4 |
| Storage | Storeat+4°C |
| Purity | ≥95%(HPLC) |
| CASNumber | 83654-05-1 |
| PubChemID | 5063 |
| InChIKey | RXSVYGIGWRDVQC-UHFFFAOYSA-N |
| Smiles | O=C(NCCCCCCNC(O/N=C2CCCCC2)=O)O/N=C1CCCCC/1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.45 | 100 | |
| ethanol | 39.45 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight394.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.53mL | 12.67mL | 25.35mL |
| 5mM | 0.51mL | 2.53mL | 5.07mL |
| 10mM | 0.25mL | 1.27mL | 2.53mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |
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