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Description:2,3-Oxidosqualenecyclase(OSC)inhibitor;blockscholesterolsynthesis
ChemicalName:(4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
2,3-Oxidosqualenecyclase(OSC)inhibitor(IC50=6.5nM);blockscholesterolsynthesisinHepG2cells.ReducesviABIlityofbreastcancercelllines.AlsoinhibitsEbolavirus(EBOV)cellentry(IC50=1.74μM).
CompoundLibraries
Ro48-8071fumarateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 564.44 |
Formula | C23H27BrFNO2.C4H4O4 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 189197-69-1 |
PubChemID | 9959583 |
InChIKey | XCYAYLWZCRGKDS-WLHGVMLRSA-N |
Smiles | FC1=C(C(C2=CC=C(Br)C=C2)=O)C=CC(OCCCCCCN(C)CC=C)=C1.OC(/C=C/C(O)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 56.44 | 100 | |
water | 11.29 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight564.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.77mL | 8.86mL | 17.72mL |
5mM | 0.35mL | 1.77mL | 3.54mL |
10mM | 0.18mL | 0.89mL | 1.77mL |
50mM | 0.04mL | 0.18mL | 0.35mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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