BiologicalActivity
SelectiveΔ6desaturaseinhibitor(IC50=0.2μMinvitro).DisplaysselectivityoverΔ5andΔ9desaturases(IC50valuesare>200μMinvitro).Exhibitsanti-inflammatorypropertiesinamouseedemamodel.EliminatesCSCsfromovariancancercelllinesandinhibitssphereformationinvitro.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 423.55 |
| Formula | C27H29N5 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 218136-59-5 |
| PubChemID | 9845201 |
| InChIKey | QFYKXKMYVYOUNJ-JBASAIQMSA-N |
| Smiles | N#CC(C3=CC=CC=C3)(C4=CC=CC=C4)CCCN1CCN(/N=C/C2=CN=CC=C2)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight423.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.36mL | 11.8mL | 23.61mL |
| 5mM | 0.47mL | 2.36mL | 4.72mL |
| 10mM | 0.24mL | 1.18mL | 2.36mL |
| 50mM | 0.05mL | 0.24mL | 0.47mL |
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