BiologicalActivity
CarboxylesteraseCes3andCes1finhibitor(IC50valuesare~100nM).AlsoinhibitsABHD6.Exhibitsminimalactivityagainstapanelofotherserinehydrolases.PromoteslipidstorageinADIpocytes.Reducesweightgainindiet-inducedobesemiceandenhancesglucosetoleranceindiabeticmice.Orallyactive.
CompoundLibraries
WWL113isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 466.53 |
| Formula | C29H26N2O4 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 947669-86-5 |
| PubChemID | 17759482 |
| InChIKey | AKIIPHDGVCFVCC-UHFFFAOYSA-N |
| Smiles | CN(C(OC3=CC=C(C4=CC=C(C(OCC)=O)C=C4)C=C3)=O)CC1=CC=CC(C2=CC=NC=C2)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.33 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight466.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.14mL | 10.72mL | 21.43mL |
| 5mM | 0.43mL | 2.14mL | 4.29mL |
| 10mM | 0.21mL | 1.07mL | 2.14mL |
| 50mM | 0.04mL | 0.21mL | 0.43mL |
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