
Overview:
Kinase insert domain receptor (KDR or VEGFR) is a growth factor receptor tyrosine kinase that plays a pivotal role in endothelial cell proliferation and differentiation. KDR binds VEGF with high affinity and this interaction is implicated in angiogenesis (1). The expression levels of VEGF and KDR are highly correlated during the normal development of the ocular vasculature in humans (1). Induction of angiogenesis is a critical step in tumor progression, and inhibitors of KDR have been demonstrated both to promote tumor regression and reduce metastatic potential in preclinical studies (2). Autophosphorylation of KDR occurs at Tyr951, Tyr996, Tyr1054 and Tyr1059 and phosphorylation at Tyr1214 is associated with interactions with downstream effector molecules (3).
ebiomall.com






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也就是说只要是兔子产生的抗体,羊抗兔(也叫抗抗体或者2抗)都可与之结合。
兔子产生的是一级抗体
羊的为二级抗体
在试验中,二抗经常被做了手脚,打上了标记,比如辣根过氧化物酶,经常被用在ELISA,WESTERN等经典的生物学试验中。

