Overview:
EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.
References:
1. Wang K, et al: Epidermal growth factor receptordeficientmice have delayed primary endochondralossification because of defective osteoclastrecruitment. J. Biol. Chem. 279: 53848-53856, 2004.2. Kobayashi S, et al: EGFR mutation and resistance ofnon-small-cell lung cancer to gefitinib. New Eng. J.Med. 352: 786-792, 2005.
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抗人球蛋白试验，又称Coombs’试验，是诊断自身免疫性溶血性贫血(AIHA)的重要依据。
正常人直接与间接试验均为阴性，Coombs’试验阴性有时并不能排除AIHA
