Human B cells, also known as B lymphocytes, are white blood cells that play key roles in adaptive immune responses. They function in the humoral immunity component of the adaptive immune system by secreting antibodies, and are also classified as professional antigen presenting cells (APCs). In addition, B cells also secrete an array of cytokines that mediate Th1- and Th2-like immune responses.
The LEGENDplex™ Human B Cell Panel (13-plex) is a bead-based multiplex assay panel, which uses fluorescence-encoded beads suitable for use on various flow cytometers. This Panel focuses on 13 key targets involved in B cell function, activation, proliferation, and survival. It allows simultaneous quantification of 13 human cytokines, which include: TNF-α, IL-13, IL-4, IL-10, IL-6, IL-2, TNF-β, IFN-γ, IL-17A, IL-12p70, APRIL, BAFF, CD40L, and are collectively secreted by Be1, Be2, Breg, CD4+ lymphocytes, dendritic cells and monocytes. It provides higher detection sensitivity and broader dynamic range than traditional ELISA methods. This panel has been validated for use on cell culture supernatant, serum, and plasma samples.
The LEGENDplex™ Human B Cell Panel is designed to allow flexible customization within the panel. It can also be divided into sub-panels, such as:LEGENDplex™ Human B Effector 1 (Be1) Panel (4-plex)LEGENDplex™ Human B Effector 2 (Be2) Panel (5-plex)LEGENDplex™ Human B Effector 1/2 (Be1/2) Panel (9-plex)LEGENDplex™ Human B Cell Activator Panel (3-plex)Please visit www.biolegend.com/legendplex for more information on panel design and how to mix and match within the panel.
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抗人球蛋白试验，又称Coombs’试验，是诊断自身免疫性溶血性贫血(AIHA)的重要依据。
正常人直接与间接试验均为阴性，Coombs’试验阴性有时并不能排除AIHA
