The 2D10.4 antibody reacts with human CD80, a 60 kDa glycoprotein that is a member of the Ig superfamily. CD80, also known as B7-1, is a ligand for the T cell receptors CD28 and CTLA-4 (CD152). Along with CD86, CD80 plays a major role in regulating the activation of T cells. CD80 is expressed by activated antigen presenting cells including B cells, macrophages, and dendritic cells.
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Freeman GJ, Gray GS, Gimmi CD, Lombard DB, Zhou LJ, White M, Fingeroth JD, Gribben JG, Nadler LM. 1991. J Exp Med. Sep 1;174(3):625-631.
Azuma M, Yssel H, Phillips JH, Spits H, Lanier LL. 1993. J Exp Med. Mar1;177(3):845-850.
Linsley PS, Bradshaw J, Greene J, Peach R, Bennett KL, Mittler RS. 1996. Immunity. Jun;4(6):535-543.
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抗人球蛋白试验,又称Coombs’试验,是诊断自身免疫性溶血性贫血(AIHA)的重要依据。
正常人直接与间接试验均为阴性,Coombs’试验阴性有时并不能排除AIHA

