The G28.5 antibody reacts with human CD40, a 45-48 kDa glycoprotein that is a member of the TNF-receptor superfamily. CD40 is expressed on B cells, follicular dendritic cells, macrophages, endothelial cells, and fibroblasts. CD40 functions as a receptor for CD154 (CD40 ligand) and mediates a wide variety of immune and inflammatory responses including co-stimulation, B cell differentiation, isotype class switching, and germinal center formation.
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抗人球蛋白试验,又称Coombs’试验,是诊断自身免疫性溶血性贫血(AIHA)的重要依据。
正常人直接与间接试验均为阴性,Coombs’试验阴性有时并不能排除AIHA

