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avivasysbio/BCL6 ELISA Kit (Human) (OKEH07700)/96 Wells/OKEH07700

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avivasysbio/BCL6 ELISA Kit (Human) (OKEH07700)/96 Wells/OKEH07700

品牌 /

avivasysbio

货号 /

OKEH07700

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数量：

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4000-520-616

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Predicted Species Reactivity:

Human

Application:

ELISA

Kit Detection Method:

Colorimetric, OD450 nm

Kit Linearity:

Sample	1:2	1:4	1:8	1:16
serum(n=5)	112-120% (n = 20)	87-97% (n = 20)	92-101% (n = 20)	82-92% (n = 20)
EDTA plasma(n=5)	107-117% (n = 20)	83-93% (n = 20)	85-97% (n = 20)	103-113% (n = 20)
heparin plasma(n=5)	91-103% (n = 20)	103-112% (n = 20)	80-90% (n = 20)	85-93% (n = 20)

Kit Principle:

Aviva Systems Biology BCL6 ELISA Kit (Human) (OKEH07700) is based on standard sandwich enzyme-linked immuno-sorbent assay technology. An antibody specific for BCL6 has been pre-coated onto a 96-well plate (12 x 8 Well Strips) and blocked. Standards or test samples are added to the wells, incubated and removed. A biotinylated detector antibody specific for BCL6 is added, incubated and followed by washing. Avidin-Peroxidase Conjugate is then added, incubated and unbound conjugate is washed away. An enzymatic reaction is produced through the addition of TMB substrate which is catalyzed by HRP generating a blue color product that changes yellow after adding acidic stop solution. The density of yellow coloration read by absorbance at 450 nm is quantitatively proportional to the amount of sample BCL6 captured in well.

Kit Range:

0.156 - 10ng/mL

Kit Recovery:

Mean recovery when spiking into sample matrices at concentrations within the dynamic range: 91% (n = 20)

Kit Reproducibility:

Mean Intra-assay CV%: <=2.8% (n="">Mean Inter-assay CV%: <=8.3% (n="">

Kit Component:

Component	Amount
BCL6 Microplate	96 Wells (12 x 8 Well strips)
BCL6 Lyophilized Standard	2
100X Biotinylated BCL6 Detector Antibody	1 x 120 uL
100X Avidin-HRP Conjugate	1 x 120 uL
Sample Diluent	1 x 20 mL
Detector Antibody Diluent	1 x 12 mL
Conjugate Diluent	1 x 12 mL
25X Wash Buffer	1 x 30 mL
TMB Substrate	1 x 10 mL
Stop Solution	1 x 10 mL

Additional Information:

Function: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5"-TTCCTAGAA-3" (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

:::

Subcellular Location: Nucleus

:::

Unigene: Hs.478588SMR: P41182String: 9606.ENSP00000232014

:::

KEGG: hsa:604MIM: 109565Pfam: PF00651

:::

KEGG: hsa:604MIM: 109565Pfam: PF00651

Reconstitution and Storage:

Store as indicated in product manual.

Sensitivity:

0.081ng/mL

Datasheets/Manuals:

Click here to download product manual. As variation between lots may occur, always reference the lot-specific manual received with each kit.

Specificity:

Natural and recombinant Human B-cell lymphoma 6 protein

Assay Info:

Assay Methodology: Quantitative Sandwich ELISA

Gene Symbol:

BCL6

Official Gene Full Name:

BCL6 transcription repressor

Alias Symbols:

BCL5, LAZ3, BCL6A, ZNF51, ZBTB27

NCBI Gene Id:

604

Protein Name:

B-cell lymphoma 6 protein

Description of Target:

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Swissprot Id:

P41182

Protein Accession #:

NP_001124317.1

Nucleotide Accession #:

NM_001130845.1

Tissue Tool:

Find tissues and cell lines supported by DNA array analysis to express BCL6.

RNA Seq:

Find tissues and cell lines supported by RNA-seq analysis to express BCL6.

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