The 3G8 monoclonal antibody reacts with the 50-65kD transmembrane form of human CD16 (FCGR3A). CD16 is the low affinity IgG receptor III and is expressed on NK cells and macrophages. CD16 participates in signal transduction and mediates antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells. The second form of CD16 (FCGR3B) is a glycosyl-phosphatidylinositol (GPI) linked molecule expressed exclusively on neutrophils.
Fleit HB, Wright SD, Unkeless JC. 1982. Proc Natl Acad Sci U S A. May;79(10):3275-3279.
Windebank KP, Abraham RT, Powis G, Olsen RA, Barna TJ, Leibson PJ. 1988. J Immunol. Dec 1;141(11):3951-3957.
Fleit HB. 1991. Clin Immunol Immunopathol. May;59(2):222-235.
Wirthmueller U, Kurosaki T, Murakami MS, Ravetch JV. 1992. J Exp Med. May 1;175(5):1381-1390.
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抗人球蛋白试验,又称Coombs’试验,是诊断自身免疫性溶血性贫血(AIHA)的重要依据。
正常人直接与间接试验均为阴性,Coombs’试验阴性有时并不能排除AIHA

