
BMS 961Selective RARγ agonist |
Sample solution is provided at 25 µL, 10mM.
































Quality Control & MSDS
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- Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure


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Cas No. | 185629-22-5 | SDF | Download SDF |
Chemical Name | (S)-3-fluoro-4-(2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetamido)benzoic acid | ||
Canonical SMILES | FC1=CC(C(O)=O)=CC=C1NC([C@H](C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)O)=O | ||
Formula | C23H26FNO4 | M.Wt | 399.46 |
Solubility | <39.95mg l="" in="" dmso="">39.95mg> | Storage | Store at -20°C |
Physical Appearance | Off-white solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. |
BMS961 is a potent and selective retinoic acid receptor gamma (RARγ) agonist with IC50 values of 30 nM.
RARγ belongs to the family of nuclear receptors which regulates transcription. RARγ mediates the anti-proliferative and apoptotic effects of retinoids in cancer cells such as neuroblastoma cells.RARγ is the principal receptor that regulates RA mediated growth arrest in keratinocytes.
In vitro, application of BMS961on mouse ear skin was found to cause a significant increase of thymic stromal lymphopoietin (TSLP) transcripts1. In addition, exposure of BMS861 on limbs at low concentration leads to retarded growth of the zeugopod (long bones) and intactness of autopod (paw). However, high concentration of BMS961treatment caused equal undifferentiation of both limb regions 2.
In WT mice, RARγ agonists BMS961treatment resulted in an increase of the ear TSLP transcripts and serum TSLP, which indicates an involvement of RAR-mediated events in transcriptional activation of TSLP expression1.
References:1. Li M, Hener P, Zhang Z, et al. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(31):11736-11741.2. Galdones E, Hales BF. Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro. Toxicological sciences : an official journal of the Society of Toxicology. 2008;106(1):223-232.
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磁珠如贴片磁珠,插件磁珠
他们都可能是同一种材质,非要区别那可能就是大小了 ,磁珠都非常的小,
电感多用于电源滤波回路,磁珠多用于信号回路,用于EMC对策磁珠主要用于抑制电磁辐射干扰,而电感用于这方面则侧重于抑制传导性干扰。两者都可用于处理EMC、EMI问题。磁珠是用来吸收超高频信号,象一些RF电路,PLL,振荡电路,含超高频存储器电路(DDR SDRAM,RAMBUS等)都需要在电源输入部分加磁珠,而电感是一种蓄能元件,用在LC振荡电路,中低频的滤波电路等,其应用频率范围很少超过错50MHZ。地的连接一般用电感,电源的连接也用电感,而对信号线则采用磁珠?
但实际上磁珠应该也能达到吸收高频干扰的目的啊?而且电感在高频谐振以后都不能再起电感的作用了,先必需明白EMI的两个途径,即:辐射和传导,不同的途径采用不同的抑制方法。前者用磁珠,后者用电感。对于扳子的IO部分,是不是基于EMC的目的可以用电感将IO部分和扳子的地进行隔离,比如将USB的地和扳子的地用10uH的电感隔离可以防止插拔的噪声干扰地平面?电感一般用于电路的匹配和信号质量的控制上。在模拟地和数字地结合的地方用磁珠。在模拟地和数字地结合的地方用磁珠。数字地和模拟地之间的磁珠用多大,磁珠的大小(确切的说应该是磁珠的特性曲线),取决于你需要磁珠吸收的干扰波的频率,为什么磁珠的单位和电阻是一样的呢??都是欧姆!!磁珠就是阻高频嘛,对直流电阻低,对高频电阻高,不就好理解了吗, 比如1000R@100Mhz就是说对100M频率的信号有1000欧姆的电阻,因为磁珠的单位是按照它在某一频率产生的阻抗来标称的,阻抗的单位也是欧姆。磁珠的datasheet上一般会附有频率和阻抗的特性曲线图。一般以100MHz为标准,比如2012B601,就是指在100MHz的时候磁珠的Impedance为600欧姆。
电感多用于电源滤波回路,磁珠多用于信号回路,用于EMC对策磁珠主要用于抑制电磁辐射干扰,而电感用于这方面则侧重于抑制传导性干扰。两者都可用于处理EMC、EMI问题。磁珠是用来吸收超高频信号,象一些RF电路,PLL,振荡电路,含超高频存储器电路(DDR SDRAM,RAMBUS等)都需要在电源输入部分加磁珠,而电感是一种蓄能元件,用在LC振荡电路,中低频的滤波电路等,其应用频率范围很少超过错50MHZ。地的连接一般用电感,电源的连接也用电感,而对信号线则采用磁珠?
但实际上磁珠应该也能达到吸收高频干扰的目的啊?而且电感在高频谐振以后都不能再起电感的作用了,先必需明白EMI的两个途径,即:辐射和传导,不同的途径采用不同的抑制方法。前者用磁珠,后者用电感。对于扳子的IO部分,是不是基于EMC的目的可以用电感将IO部分和扳子的地进行隔离,比如将USB的地和扳子的地用10uH的电感隔离可以防止插拔的噪声干扰地平面?电感一般用于电路的匹配和信号质量的控制上。在模拟地和数字地结合的地方用磁珠。在模拟地和数字地结合的地方用磁珠。数字地和模拟地之间的磁珠用多大,磁珠的大小(确切的说应该是磁珠的特性曲线),取决于你需要磁珠吸收的干扰波的频率,为什么磁珠的单位和电阻是一样的呢??都是欧姆!!磁珠就是阻高频嘛,对直流电阻低,对高频电阻高,不就好理解了吗, 比如1000R@100Mhz就是说对100M频率的信号有1000欧姆的电阻,因为磁珠的单位是按照它在某一频率产生的阻抗来标称的,阻抗的单位也是欧姆。磁珠的datasheet上一般会附有频率和阻抗的特性曲线图。一般以100MHz为标准,比如2012B601,就是指在100MHz的时候磁珠的Impedance为600欧姆。

