BiologicalActivity
Annexin/lipocortin1-mimeticpeptide;inhibitsleukocyteextravasation.Reducesneutrophiladhesionandemigration,promotesdetachmentofneutrophilsfromactivatedmesentericendotheliumandacceleratesepithelialwoundrepairafterinducedcolonicinjuryinmiceinvivo.Anti-inflammatory.
LicensingInformation
SoldunderlicensefromTheWilliamHarveyResearchInstitute
TechnicalData
| M.Wt | 3089.46 |
| Formula | C141H210N32O44S |
| Sequence | AMVSEFLKQAWFIENEEQEYVQTVK (Modifications:Ala-1=N-terminalAc) |
| Storage | Desiccateat-20°C |
| CASNumber | 151988-33-9 |
| PubChemID | 16138723 |
| InChIKey | ODWGEWZOPBDSHW-ISLQBSBZSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinPBS |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight3089.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.32mL | 1.62mL | 3.24mL |
| 5mM | 0.06mL | 0.32mL | 0.65mL |
| 10mM | 0.03mL | 0.16mL | 0.32mL |
| 50mM | 0.01mL | 0.03mL | 0.06mL |
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