
Serum-SalivaCorrelation | 0.64 |
Sensitivity | 3pg/mL |
SampleTestVolume | 50μL |
RecommendedCollectionVolume | 125μL* |
SpecialConsiderations | No |
CollectionProtocol | DownloadPDF |
17Alpha-OHP(17alpha-hydroxyprogesteroneor17α-hydroxyprogesterone)isa steroidhormone producedintheadrenalglandandgonads.(1,2,3) Itissynthesizedfromprogesterone,anditservesprimarilyasaprecursorcompoundthatisconvertedintocortisolintheadrenalgland,orintoandrogenicandestrogenicsteroidhormonesinthegonads.(3,4)17α-OHPisroutinelyusedforthediagnosticassessmentof21-hydroxylasedeficiency,whichislinkedtocongenitaladrenalhyperplasia,impairedaldosteronesynthesis,andfatalsalt-wasting.(5,6,7,8,9) 17α-OHPexhibitsadiurnalrhythmwithhighervaluesinthemorninganddecreasingoverthedaytoanADIrintheevening.(10,11)17α-OHPenterssalivafrombloodviaintracellularmechanisms,andthereisexcellentcorrelationbetweensalivaandserumvalues.(12)
- Pasquali,R.,Patton,L.,Pocognoli,P.,etal.(2007). 17-Hydroxyprogesteroneresponsestogonadotropin-releasinghormonedisclosedistinctphenotypesoffunctionalovarianhyperandrogenismandpolycysticovarysyndrome. JClinEndocrinMetab,92(11),4208-17.
- Şahin,Y.,Keleştimur,F.(1997).17-Hydroxyprogesteroneresponsestogonadotrophin-releasinghormoneagoNISTbuserelinandadrenocorticotrophininpolycysticovarysyndrome:InvestigationofadrenalandovariancytochromeP450c17αdysregulation. HumReprod,12(5),910-13.
- Strott,C.A.,Yoshimi,T.,Lipsett,M.B.(1969). Plasmaprogesteroneand17-hydroxyprogesteroneinnormalmenandchildrenwithcongenitaladrenalhyperplasia. JClinInvest,48(5),930-39.
- Weliky,I.,Engel,L.L.(1962). Metabolismofprogesterone-4-C14andpregnenolone-7α-H3byhumanadrenaltissue. JBiolChem,238(4),1302-7.
- Santos,C.M.,Abad,L.R.,Cua,S.C.&Domingo,C.F.(2003).Monitoringcongenitaladrenalhyperplasiausingbloodspot17-hydroxyprogesteroneassay.SoutheastAsianJTropMedPublicHealth,34(Suppl3),174-8.
- Sack,J.,Front,H.,Kaiserman,I.,Schreiber,M.(1997).21-hydroxylasedeficiency:ScreeningandincidenceinIsrael.HormRes,48(3),115-9.
- New,M.I.,Levine,L.S.(1984).Congenitaladrenalhyperplasia.MonographsonEndocrinology,26,1-88.
- VanderKamp,H.J,Wit,J.M.(2004).Neonatalscreeningforcongenitaladrenalhyperplasia.EurJEndocrinol,151(Suppl.3),U71-5.
- Hughes,I.A.,Winter,J.S.(1976). Theapplicationofaserum17-OHprogesteroneradioimmunoassaytothediagnosisandmanagementofcongenitaladrenalhyperplasia.JPediatrics,88(5),766-73.
- Gröschl,M.,Rauh,M.,Dörr,H.-G.(2003). Circadianrhythmofsalivarycortisol,17α-hydroxyprogesterone,andprogesteroneinhealthychildren. ClinChem,49(10),1688-91.
- Goudas,V.T.,Dumesic,D.A.(1997). Polycysticovarysyndrome. EndocrinolMetabClinNorthAm,26(4),893-912.
- Vining,R.F.,McGinley,R.A.(1987). Themeasurementofhormonesinsaliva:Possibilitiesandpitfalls. JSterBiochem,27(1-3),81-94.
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(1)优级纯试剂 亦称保证试剂,为一级品,纯度高,杂质极少,主要用于精密分析和科学研究,常以GR表示。
(2)分析纯试剂 亦称分析试剂,为二级品,纯度略低于优级纯,杂质含量略高于优级纯,适用于重要分析和一般性研究工作,常以AR表示。
(3)化学纯试剂 为三级品,纯度较分析纯差,但高于实验试剂,适用于工厂、学校一般性的分析工作,常以CP表示。
(4)实验试剂 为四级品,纯度比化学纯差,但比工业品纯度高,主要用于一般化学实验,不能用于分析工作,常以 LR表示。
以上按试剂纯度的分类法已在我国通用。根据化学工业部颁布的“化学试剂包装及标志”的规定,化学试剂的不同等级分别用各种不同的颜色来标志,见表1。
表1 我国化学试剂的等级及标志
bhclna2so4nano3na2co3
chclnaohna2co3nacl
dba(oh)2nahco3alcl3nahso4
刚入这行,谢谢大家
A.H2SO4Na2SO4AgNO3BaCl2.
B.NaOHNa2CO3NaHSO4MgCl2
C.CaCl2NaNO3MgSO4BaCl2
D.HNO3KOHKClK2CO3


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