
Serum-SalivaCorrelation | NA |
Sensitivity | 7ng/mL |
SampleTestVolume | 25μL |
RecommendedCollectionVolume | 75μL* |
SpecialConsiderations | No |
CollectionProtocol | DownloadPDF |
Chromogranin A(CgA,alsoknownasparathyroidsecretoryprotein1)isanacidicsecretoryproteinbelongingtothegraninfamily,foundinmanytypesofneuroendocrinetissues. Itisstoredinsecretoryvesicleswithothertypesofneurotransmittersandpeptidehormones. Graninsplayanimportantroleinthesortingandaggregationofsecretoryproductsinthetrans-golginetwork,andinthesubsequentformationofsecretorygranules.(1,2,3,4,5) CgAisco-secretedfromsympatheticnervesalongwiththecatecholamines,andithasbeenshowntobeusefulasabioMarkerofsympatheticnervousactivity.CgAproductionhasbeenfoundinhumansuBMAndibularsalivaglands,andCgAcanbemeasuredinsaliva.ThecorrelationbetweensalivaandserumCgAisnotwellunderstood.(5,6,7)AcircADIanrhythmforCgAinnormalsubjectshasbeenreported,withpeakvaluesduringthenightaround11:00andanadirinthemorningaround8:00.(8)
- Feldman,S.A.,Eiden,L.E.(2003).Thechromogranins:Theirrolesinsecretionfromneuroendocrinecellsandasmarkersforneuroendocrineneoplasia. EndocrPathol,14(1),3-23.
- O,Connor,D.T.,Frigon,R.P.,Sokoloff,R.L.(1984). HumanchromograninA.Purificationandcharacterizationfromcatecholaminestoragevesiclesofhumanpheochromocytoma. Hypertension,6,2-12.
- (Ozawa,H.,Takata,K.(1995).Thegraninfamily--Itsroleinsortingandsecretorygranuleformation.CellStructFunct,20,415-20.)
- Montero-Hadjadje,M.,Vaingankar,S.,Elias,S.,etal.(2008). ChromograninsAandBandsecretograninII:Evolutionaryandfunctionalaspects. ActaPhysiol(Oxf),192(2),309-24.
- Helle,K.B.(2010). ChromograninsAandBandsecretograninIIasprohormonesforregulatorypeptidesfromthediffuseneuroendocrinesystem. ResultsProblCellDiffer,50,21-44.
- Koh,D.S.-Q.,Koh,G.C.-H.(2007). Theuseofsalivarybiomarkersinoccupationalandenvironmentalmedicine. OccupEnvironMed,64,202-10.
- Kanno,T.(2004).CompoundexocytosisofsecretorygranulescontainingsalivarychromograninAingranularductcellsinratsubmandibulargland:ThelaststudyincollaborationwiththelateprofessorNoboruYanaiharaatYanaiharaInstitute. RegPeptides,123,3-7.
- Giampaolo,B.Angelica,M.,Antonio,S.(2002). Chromogranin Ainnormalsubjects,essentialhypertensivesandadrenalectomizedpatients. ClinEndocrinol(Oxf),57,41-50.
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(1)优级纯试剂 亦称保证试剂,为一级品,纯度高,杂质极少,主要用于精密分析和科学研究,常以GR表示。
(2)分析纯试剂 亦称分析试剂,为二级品,纯度略低于优级纯,杂质含量略高于优级纯,适用于重要分析和一般性研究工作,常以AR表示。
(3)化学纯试剂 为三级品,纯度较分析纯差,但高于实验试剂,适用于工厂、学校一般性的分析工作,常以CP表示。
(4)实验试剂 为四级品,纯度比化学纯差,但比工业品纯度高,主要用于一般化学实验,不能用于分析工作,常以 LR表示。
以上按试剂纯度的分类法已在我国通用。根据化学工业部颁布的“化学试剂包装及标志”的规定,化学试剂的不同等级分别用各种不同的颜色来标志,见表1。
表1 我国化学试剂的等级及标志
bhclna2so4nano3na2co3
chclnaohna2co3nacl
dba(oh)2nahco3alcl3nahso4
刚入这行,谢谢大家
A.H2SO4Na2SO4AgNO3BaCl2.
B.NaOHNa2CO3NaHSO4MgCl2
C.CaCl2NaNO3MgSO4BaCl2
D.HNO3KOHKClK2CO3


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