
Serum-SalivaCorrelation | NA |
Sensitivity | 0.07pg/mL |
SampleTestVolume | 60μL |
RecommendedCollectionVolume | 135μL* |
SpecialConsiderations | No |
CollectionProtocol | DownloadPDF |
Interleukin-6(IL-6)isoneofafamilyofBIOLOGicallyactivesmallproteinmoleculesknownascytokines. Itisreleasedbyavarietyoftissues,includingactivatedleukocytes,ADIpocytes,andendothelialcells,anditisinvolvedinmanyprocessesinthebody. IL-6playsanimportantroleinstimulatingtheimmuneresponsetoinfectionortraumabyinducingtheproductionofacute-phaseproteinssuchasCRPandbyfeverinduction. (1,2,3) Inadditiontoitspro-inflammatoryrole,IL-6alsohasanti-inflammatoryproperties.(4) MessengerRNAforIL-6hasbeenfoundintissuesofhealthyhumanlABIalsalivaryglands,andtheexpressionlevelsofthemRNAswereeitherup-ordown-regulatedbyadjacentfocalinfiltratinglymphoidcells.Theepithelialcellsinthesalivaryglandsareactiveparticipantsintheautoimmune-mediatedprocessofSjögren’ssyndrome,andsalivarylevelsofIL-6areincreasedinthatdisease.(5,6) SalivaryIL-6levelsarealsoincreasedinperiodontaldisease.(7)
ResearchershavefoundrelationshipsbetweensalivaryIL-6andsleepdysfunction,psychosocialfactors,andstress.(8,9,10) AstudywithmicehasshownthatnormalparotidacinarcellssynthesizeIL-6andstoreitinsecretorygranules. TheIL-6isreleasedfromthegranulesfollowingα-andβ-adrenergicstimulation.(11)
- McCarty,M.F.(1999).Interleukin-6asacentralmediatorofcardiovascularriskassociatedwithchronicinflammation,smoking,diabetes,andvisceralobesity:Down-regulationwithessentialfattyacids,ethanolandpentoxifylline. MedHypotheses,52(5),465-77.
- Castell,J.V.,Gomez-Lechon,M.J.,David,M.,etal.(1990). Acute-phaseresponseofhumanhepatocytes:Regulationofacute-phaseproteinsynthesisbyinterleukin-6. Hepatology,12(5),1179-86.
- Chai,Z.,Gatti,S.,Toniatti,C.,etal.(1996).Interleukin(IL)-6geneexpressioninthecentralnervoussystemisnecessaryforfeverresponsetolipopolysaccharideorIL-1β:AstudyonIL-6-deficientmice. JExpMed,183(1),311-16.
- Tilg,H.,Trehu,E.,Atkins,M.B.(1994). Interleukin-6(IL-6)asananti-inflammatorycytokine:InductionofcirculatingIL-1receptorantagoNISTandsolubletumornecrosisfactorreceptorp55. Blood,83(1),113-18.
- Sun,D.,Emmert-Buck,M.R.,Fox,P.C.(1998). DifferentialcytokinemRNAexpressioninhumanlabialminorsalivaryglandsinprimarySjögren’ssyndrome. Autoimmunity,28(3),125-37.
- Tishler,M.,Yaron,I.,Shirazi,I.,etal.(1999). Increasedsalivaryinterleukin-6levelsinpatientswithprimarySjögren’ssyndrome. RheumatolInt,18(4),125-27.
- Costa,P.P.,Trevisan,G.L.,Macedo,G.O.,etal. (2010). Salivaryinterleukin-6,matrixmetalloproteinase-8,andosteoprotegerininpatientswithperiodontitisanddiabetes. JPeriodontology,81(3),384-91.
- El-Sheikh,M.,Buckhalt,J.A.,Granger,D.A.,etal.(2007). Theassociationbetweenchildren’ssleepdisruptionandsalivaryinterleukin-6. JSleepRes,16(2),188-97.
- Sjögren,E.,Leanderson,P.,Kristenson,M.,Ernerudh,J.(2006). Interleukin-6levelsinrelationtopsychosocialfactors:Studiesonserum,saliva,andinvitroproductionbybloodmononuclearcells. BrainBehavImmun,20(3),270-78.
- Groer,M.,Murphy,r.,bunnell,W.,etal.(2010). Salivarymeasuresofstressandimmunityinpoliceofficersengagedinsimulatedcriticalincidentscenarios. JOccupEnvironMed,52(6),595-602.
- Tanda,N.,Ohyama,H.,Yamakawa,M.,etal.(1998).IL-1βandIL-6inmouseparotidacinarcells:Characterizationofsynthesis,storage,andrelease. AmJPhysiol,274(1Pt1),G147-56.
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(1)优级纯试剂 亦称保证试剂,为一级品,纯度高,杂质极少,主要用于精密分析和科学研究,常以GR表示。
(2)分析纯试剂 亦称分析试剂,为二级品,纯度略低于优级纯,杂质含量略高于优级纯,适用于重要分析和一般性研究工作,常以AR表示。
(3)化学纯试剂 为三级品,纯度较分析纯差,但高于实验试剂,适用于工厂、学校一般性的分析工作,常以CP表示。
(4)实验试剂 为四级品,纯度比化学纯差,但比工业品纯度高,主要用于一般化学实验,不能用于分析工作,常以 LR表示。
以上按试剂纯度的分类法已在我国通用。根据化学工业部颁布的“化学试剂包装及标志”的规定,化学试剂的不同等级分别用各种不同的颜色来标志,见表1。
表1 我国化学试剂的等级及标志
bhclna2so4nano3na2co3
chclnaohna2co3nacl
dba(oh)2nahco3alcl3nahso4
刚入这行,谢谢大家
A.H2SO4Na2SO4AgNO3BaCl2.
B.NaOHNa2CO3NaHSO4MgCl2
C.CaCl2NaNO3MgSO4BaCl2
D.HNO3KOHKClK2CO3


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