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Tocris/AT 101/3367/10/10 mg
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Tocris/AT 101/3367/10/10 mg
品牌 / 
Tocris
货号 / 
3367/10
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4000-520-616
Description:DownregulatesBcl-2andMcl-1;pro-apoptotic
ChemicalName:(-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

R-(-)-enantiomerofgossypol(Cat.No.1964).MimicstheBH3domainsofBcl-2,Bcl-XLandMcl-1.DisruptsheterodimerizationofBcl-2withproapoptoticfamilymembers.Inducesapoptosisinvitrothroughactivationofcaspase-9;cytotoxictomultiplemyelomaanddrug-resistantcelllines.Delaysonsetofandrogen-independentgrowthofVCaPprostatecancerxenograftsinvivo.

CompoundLibraries

AT101isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt518.56
FormulaC30H30O8
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber90141-22-3
PubChemID3503
InChIKeyQBKSWRVVCFFDOT-UHFFFAOYSA-N
SmilesOC1=C(C3=C(O)C(C(C=O)=C(O)C(O)=C4C(C)C)=C4C=C3C)C(C)=CC2=C1C(C=O)=C(O)C(O)=C2C(C)C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO51.86100
ethanol51.86100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight518.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.93mL9.64mL19.28mL
5mM0.39mL1.93mL3.86mL
10mM0.19mL0.96mL1.93mL
50mM0.04mL0.19mL0.39mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet