进口Tocris试剂盒，血清清关 Tocris Bioscience报价单,Tocris/AT 101/3367/10/10 mg,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/AT 101/3367/10/10 mg

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Tocris

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3367/10

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4000-520-616

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Description:DownregulatesBcl-2andMcl-1;pro-apoptotic

ChemicalName:(-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

R-(-)-enantiomerofgossypol(Cat.No.1964).MimicstheBH3domainsofBcl-2,Bcl-XLandMcl-1.DisruptsheterodimerizationofBcl-2withproapoptoticfamilymembers.Inducesapoptosisinvitrothroughactivationofcaspase-9;cytotoxictomultiplemyelomaanddrug-resistantcelllines.Delaysonsetofandrogen-independentgrowthofVCaPprostatecancerxenograftsinvivo.

CompoundLibraries

AT101isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	518.56
Formula	C₃₀H₃₀O₈
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	90141-22-3
PubChemID	3503
InChIKey	QBKSWRVVCFFDOT-UHFFFAOYSA-N
Smiles	OC1=C(C3=C(O)C(C(C=O)=C(O)C(O)=C4C(C)C)=C4C=C3C)C(C)=CC2=C1C(C=O)=C(O)C(O)=C2C(C)C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	51.86	100
	ethanol	51.86	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight518.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.93mL	9.64mL	19.28mL
5mM	0.39mL	1.93mL	3.86mL
10mM	0.19mL	0.96mL	1.93mL
50mM	0.04mL	0.19mL	0.39mL

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BiologicalActivity

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